TB-500

TB-500 is a synthetic peptide corresponding to the actin-binding domain of Thymosin Beta-4 (Tβ4), a 43 amino acid G-actin sequestering protein that is one of the most abundant intracellular peptides in mammalian cells. TB-500 retains the LKKTET actin-binding sequence critical for Tβ4's biological function.
Actin-Binding and Cytoskeletal Research
Research has examined TB-500's interactions with G-actin monomers and its effects on the G-actin/F-actin ratio in cellular models. Studies have investigated its influence on cytoskeletal reorganization, lamellipodia formation, and cell polarity establishment in migrating cell models.
Cellular Migration and Wound Response Research
A significant area of TB-500 research involves its effects on cellular migration in wound healing and tissue repair experimental models. Studies have examined its influence on endothelial cell migration, fibroblast recruitment, and epithelial cell sheet movement.
Angiogenesis and Anti-Inflammatory Research
Research has examined Thymosin Beta-4 and TB-500's interactions with angiogenic signaling, including their effects on endothelial cell sprouting, tube formation, and VEGF expression in experimental angiogenesis models.
• Goldstein AL et al. (2005). Thymosin beta4: a multi-functional regenerative peptide. Annals of the New York Academy of Sciences, 1054, 1–8.

• Molecular Weight: ~2888 g/mol
• CAS Number: 77591-33-4
• Sequence / Structure: Active fragment of Thymosin Beta-4 containing the LKKTET actin-binding sequence (synthetic analogue)
• Form: Lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: Per Certificate of Analysis

Every batch is independently tested by Brown Institute of Biomolecular Research. It confirms compound identity and verified purity of 99% or higher.

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