SLU-PP-332 is a synthetic small molecule agonist of the estrogen-related receptor (ERR) family, specifically targeting ERRα, ERRβ, and ERRγ. These nuclear receptors are constitutively active transcription factors that regulate genes involved in mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation — functions that overlap with transcriptional adaptations induced by endurance exercise.
ERR Nuclear Receptor Research
Research has examined SLU-PP-332's binding interactions with ERRα, ERRβ, and ERRγ ligand-binding domains and its capacity to enhance the transcriptional activity of these constitutively active receptors above their basal levels.
Mitochondrial Biogenesis and Exercise Mimicry Research
A key area of SLU-PP-332 research involves its effects on PGC-1alpha coactivation and downstream mitochondrial biogenesis gene programs in skeletal muscle experimental models. Research has examined its effects on mitochondrial number and oxidative fiber type markers in rodent muscle tissue.
Metabolic Gene Expression Research
Preclinical studies have examined SLU-PP-332's effects on fatty acid oxidation gene expression, including PDK4, CPT1, ACADM, and HADHA in experimental muscle and liver models.
• Kim J et al. (2023). SLU-PP-332 activates a vigorous exercise gene program in skeletal muscle. Nature Communications, 14(1), 7495.
