HCG (HUMAN CHORIONIC GONADOTROPIN)

Human Chorionic Gonadotropin (HCG) is a heterodimeric glycoprotein hormone consisting of an alpha subunit (92 amino acids) shared with LH, FSH, and TSH, and a unique beta subunit (145 amino acids) that confers receptor specificity. It signals through the LH/hCG receptor (LHCGR), a G protein-coupled receptor expressed predominantly in gonadal tissue.
LH/HCG Receptor Interaction Research
Preclinical and clinical research has extensively examined HCG's interactions with the LH/hCG receptor and downstream cAMP/PKA signaling cascades in Leydig cells of the testis and granulosa/luteal cells of the ovary.
Steroidogenesis Pathway Research
Research has examined HCG's role in stimulating testosterone biosynthesis in Leydig cell models, including its effects on steroidogenic acute regulatory (StAR) protein expression and CYP enzyme activity in the steroidogenic pathway.
Hypothalamic-Pituitary-Gonadal Axis Research
Research has explored HCG's influence on HPG axis regulation, including its effects on pituitary LH and FSH secretion through negative feedback mechanisms in experimental models.
• Stenvers KL & Bhavnani BR (2011). Luteinizing hormone/human chorionic gonadotropin receptor. Endocrine Reviews, 32(6), 731–787.

• Molecular Weight: ~36,700 g/mol (glycoprotein)
• CAS Number: 9002-61-3
• Sequence / Structure: Glycoprotein hormone — alpha subunit (92 aa) + beta subunit (145 aa)
• Form: Lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: Per Certificate of Analysis

Every batch is independently tested by Brown Institute of Biomolecular Research. It confirms compound identity and verified purity of 99% or higher.

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